I've been less than impressed with W10 but decided to load it in my just completed new build.
Installing it from USB was quite simple, with FSX-SE, P3Dv3, P3Dv4.5 and XP-11 all running without a hitch.
However (there's always 'however') several programs either crashed, were over run by W10 crap default programs, or just ceased to load.
The most annoying and frequent hassles were with several of my graphic programs, all of which were current (2020) releases and used frequently for photography.
So yes, it seems as if the Flight Sims work fine, as do my Race Sims.
Certainly do not risk losing any important files, a 4TB external drive is not expensive and will save any anguish if W10 goes feral.
In my case, I'm adding a new 2TB M2 drive and a new 1600W PS, then reverting to W7, after having checked all the W10 options and finding none that are available without the MS 'Crapware'!
I don't need or want Edge, Cortina, MS Paint (meh!) and the entire collection of bloatware rubbish that is me causing problems.
JFTR, it has been literally years since I've had a BSOD.......over the past couple of weeks W10 has delivered decades worth!