Great stick ain't it? Hoping I can always afford to never go back to £35-50 sticks, whilst I loved them at the time, my X52 has become my all time fav.
As for set up, I have set as many engine controls to the throttle and kept the flight controls on the stick. The three blue buttons on the throttle are for battery, starter, generator. I've set the two wheels to mixture and prop. You might have guessed I fly props most, lol. But don't worry about that, the mode switch can be used to set the buttons up for different controls, ie. mode 1 - prop stuff, mode 2 - jets, mode 3 - helo's. Just a rough idea. I also disabled the mini-stick (mouse emulation) apart from causing trouble, I found it pointless, I have a mouse and it's a damn sight easier to use. Now I can use the mouse button and wheel for other stuff :d wheel is elev trim, button is avionics master. ministick is for twiddling my thumb on long flights, it does nothing so far. The hat on the throttle is for the other trim functions.
Main hat on stick is normal, second hat toggles views(L/R) and zooms in/out (up/down). other buttons are used for brakes (second stop on trigger is thrust reverse) flaps, cowl flaps, gear, hook, tail wheel lock (pinkie button), etc, etc.
This works for me, still tweaking though and mine is a year old now, good luck, you'll love it,
Jamie