I'd give a qualified "yes". The Mossie more than proved itself as the war's most versatile and combat capable aircraft, but I don't know if I'd want to go one-on-one in her in a lengthy, intense furball with a large number of enemy single-engined fighters. Certainly she could hold her own, but I think there were other aircraft better suited to point defense (Spitfire, Tempest) or escort (Mustang). As an offensive weapon, the Mosquito's forte was as a rapid, deep penetration strike aircraft: fly low, fly fast, hit damn hard were you needed to, then get the hell out. And her other duties as Pathfinder, light bomber, strategic recce, and night fighter certainly showed she was without peer.
Would've been interesting to see how long the Luftwaffe campaign during the Battle of Britain would've lasted if the RAF had had the Mossie available to go after the German bombers; probably would've shortened the European war by a year or more!
N.