There have been some good posts on the A2A forum regarding the 377 and Accu-Sim and how to stay ahead of the game. The trick is to get it into AP on the climb out early enough (i.e. after wheels and flaps are up and she is climbing at the correct rate) so that you can get the engines changed from take-off settings to climb/cruise settings and then go back to the pilot's seat and change to the required course. After that it is a case of switching between the two seats as required. Once you are on the correct course and in AP there's actually very little work for the pilot to do and most time will be spent at the Engineer's station watching gauges and making any minor adjustments required.