I've got a twisty for my big computer and a two axis on the laptop.
I agree with simonu, it depends on the aircraft and situation. I much prefer flying with a rudder in my control, especially on air to ground support missions. That little twist of the stick to get the rudder involved really makes a difference. I also like it for take offs and landings where I have built some cross-winds into my missions.
Now, if I just had the separate throttle controls for my P-38s! My understanding from a WWII crew chief in the USAAC in England during the war, is that his pilots would talk about how they would climb away from a Messerschmidt or FW to almost stall, cut the engine on one side, full throttle the other engine and shove the rudder pedal to the floor to spin around and face the enemy pilot climbing to meet them and open up with all their guns and cannons. I have hit F5 to bring up my throttles and tried this, but it is unwieldy to do in CFS2.