Please see the most recent updates in the "Where did the .com name go?" thread. Posts number 16 and 17.
Yea, the problem I've found with most cleaners is that they either delete necessary items without giving you the option to undelete or they give you the option to look at the files it plans to delete but most people wouldn't know whether they were needed files or not just by looking at a file name. They end up doing more harm than good, pretty useless really.Just wanted to give a heads up about this registry cleaner, do not get it! It deletes important files and makes programs unusable. I've already had to re-install Microsoft Security Essentials and my photo editing software and my scanner software.

That's where some judicious cleaning is required. I rarely reboot my development machine, but when I do and it takes up to ten minutes to complete the boot process, it's well past time to clean the Registry!!!!