The "largest" airplane I've ever flown and landed for real, was a C-90... and I've got a lot of twin piston time (310, and Seneca), but most of my recent flying has been light singles.
The principles are the same.. it's all about nailing the numbers. If you're at the proper altitude, properly configured, at the proper airspeed... everything else falls into place.
The trick to flying big tubes in the sim, is the same as it is in real life. Work your way up the speed and complexity ladder. If you can't fly a perfect pattern and stabilized approach in a C172, effortlessly, you'll have your hands full in the Baron.. and so on.. up through the KingAir, Lear, CRJ, 737, and 747.
Crshing over and over until you finally don't crash, might be a luxury in simming.. but you really don't learn anything. It's not very satisfying, and will shorten your attention-span.
I don't fly the tubes often, because it's VERY difficult to do it realistically, if you aren't doing it regularly.
I've got all I can handle flight-planning, navigating and flying the C172, realistically.. :mixedsmi: