Sounds like you might have some fancy macro set up in your mouse programming software. You might check it in some other program besides FSX and see what happens. If it only happens in FSX, check to see if you have some weird keymapping in the sim that equates double-clicks with the exit program command.
I have a Wireless Logitech Mouse and keyboard. I looked at the settings and nothing there would cause this. The problem also happens in FS2004. @harleyman, IT would be from making small adjustments to the 2d or 3d Autopilot. eg: Altitude settings or airspeed settings.
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