Well I got SOME success with the flight controls. When I looked through the joystick and keyboard control assignments inside CFS2 some were all wrong, so I deleted the incorrect assignments...that got the basics working ok.
Still have the problem with the grayed out "Apply" button in the calibration routine.
Using a later software download for the profiler....made all of the main controls show up on screen, then run through the calibration routine but it doesn't hold the calibration...apply button still grayed out inactive. Version 5.09.131 05/05/2010.
Using Vista 32bit, installed ok, software recognized by M$.