Perhaps this was already covered sufficiently, but here goes anyway:
For a naturally aspirated (non supercharged) engine, the maximum manifold pressure will be the ambient pressure. Look for the "Standard Atmosphere" to figure out what it is spec'ed at for various altitudes. Local conditions may differ, but this is the benchmark.
For an unsupercharged engine, if it is not running, the pressure behind the throttle plate of your carburetor will be the same as the outside air pressure (roughly 29.8-something inches of Mercury IIRC). When you turn on the engine, the cylinders will try to draw in fuel-air. The Throttle plate in your carburetor will restrict the amount of air coming in, thus at low throttle settings, there will be a vacuum relative to outside pressure. 8 inches of Mercury isn't terribly unusual IIRC.
As you open the throttle, you reduce the restriction and the pressure differential decreases. At max (Wide Open Throttle) there will be no difference between pressure behind your throttle plate and outside pressure: 29.8-something inches Hg (Mercury).
With a supercharger, the measured pressuer behind your throttle plate may be well over ambient pressure because there is a pump which is increasing the air pressure in front of your throttle. 45 inches manifold pressure (roughly +15 inches Hg) isn't unusual. The numbers may go much higher. 72 inches manifold pressure wasn't unusual for a late WW2 fighter.
At low altitude, your supercharger may have much more capacity than your engine can take. Thus you may have several speeds for different altitude ranges. At some point, your supercharger cannot compress the thin air sufficiently to maintain maximum allowable manifold pressure. That would be your critical altitude above which your engine power falls off. Your actual critical altitude for speed is generally slightly above this because of ram effects because your aircraft is moving.
For testing, I do a quick engine power reading (using Jerry Beckwith's gauges) at 500 ft, 2500 ft, 5000 ft, and 2500 ft intervals above that to about 35,000 to 40,000 ft. You can tell when manifold pressure and engine power fall off. Maximum speed will be somewhere around there. The power check for all altitudes can be done in a couple minutes (about 10-15 seconds per altitude) because you aren't waiting for things to stabilise as you would for a maximum speed run.
Just to make it really interesting, just about all the countries in WW2 used their own system for measuring manifold pressure. I wrote a spreadsheet a couple years ago to do this conversion because at least in CFS, all the numbers are specified using the US system and it wasn't instantly obvious what German 1.42 Ata, Japanese +300 mm should be translated to in the AIR file.
Hope this helps.
- Ivan.