I bought the Saitek X52 Pro to replace my old Logitech joystick. I already have a CH throttle quadrant, so I thought that I could simply use the Saitek joystick and just connect the throttle when flying single engine jets, but as it turned out the joystick connects to the base of the throttle (which in turn connects to a USB port) so the Saitek throttle has to be connected at all times. It may be possible to connect the joystick directly to USB using a converter of some kind, I don't know.
The joystick is really good, no complaints there. With regards to the throttle, I'm not so impressed. Several buttons and part of the throttle range itself stopped working shortly after I got it. I had a look inside and reseated a couple of connectors - it is very flimsy stuff, and I suspect the wires may easily fray if I use the throttle much. The connector on the base of the throttle where the joystick connects is somewhat loose, and I frequently need to push the cable back in after moving stuff on my desk to get my joystick working again.
Another problem I've noticed is that some of the LEDs on the Joystick only work occasionally. This may be caused by insufficient power coming from the USB port - I turn them off in the driver, anyway, so not really an issue for me, but if you like looking at colored lights this is something to look out for.