I just did the same route (KAVL-KMYR) in the TBM with no issues. That plane has one repaint (mine) and a replacement model that reenables the exterior registration without breaking the door animations. (I should test again without that mod just to see if Asobo finally fixed that bug.) So either the CTD when I started my previous descent was a glitch, or SU13 has broken the DA62X mod. My money's on a glitch, since everything else still works in the mod, and what I did had nothing to do with the model. It could be the G1000, but I highly doubt it.
Edit - nope, external reg. still not displaying on stock model...