HP,
First thing I would do is look at the axis assignments of all of the hardware in the CFS2 Controller Assignments tab. Make sure each axis is assigned to the proper function. If all this is correct you can try reinstalling the software for each and doing the recalibration. These are the most common issues with axis response failures.
If your setup is the Flight Pack and all components are daisy chained together to one USB plug, the issue could be a bad USB cable, USB plug or main PC board of the components (usually located in the stick base).
Non functioning or erratic stick buttons may also be an indication that the tactile switches under the buttons are worn and need to be replaced. I've had to replace the hat switch on my Thrustmaster HOTAS Cougar stick and some of the other buttons are now showing signs of wear and may also need replacement.
Unfortunately, in our age of throw-away and replace society, repairing electronic components is no longer cost effective unless you can get the parts, have the tools necessary and do it yourself. If you decide to go this route, do not count on any technical help or diagrams from Thustmaster as their business relies on people willing to replace components when they go bad but their excellent parts department can get you the right parts if you can give them the proper name or number of the parts needed. Being in the electronics repair business myself, I have been fortunate enough to be able to repair my components as needed.
Please keep us updated on your progress as I'm sure there are many people out there who would benefit from anything you may discover.