I think there may be a little bit of misunderstanding as to what Accusim does to your flight work load in an aircraft like the B377.
I don't ever find myself feeling like I have to be the engineer or the co-pilot. I spend about as much time being the plane 'ol pilot as in just about any equivilant aircraft that I have that isn't Accusim'd.
If you follow proper pre-flight procedures and have all your ducks in a row before you even start to taxi for take-off, the rest of the flight should be fairly straight forward and panic free.
A great percentage of the perceived extra Accusim brain damage is something you better have figured out and sorted through before you throttle up.
IMO Once she's off the ground and skyward bound, the B377 fully Accusim'd is one of the most enjoyable and interesting aircraft I've flown in any sim ever. I don't move around constantly from position to position because it's required, I do it, because I enjoy all the views. For much of a flight I may just campout back in the FE seat because it has the best view of all, plus I can glance over to see how things are looking.
Even the FE panel as imposing as it looks isn't gauge after gauge of disasters waiting to happen. Most of the time all your doing is looking to see if maybe a tweak here or a tweak there to a cowl or flap might get a little more kick out of the engines.
If you find yourself constantly fighting to keep from frying an engine or toasting a set of turbo bearings then my best advice would be to land as quickly as possible and do a little more reading.
If you tend to be one of the bearing fryer & engine toaster variety of pilot, one thing to be really thankful for with the B377 versus a single engine Accusim aircraft, is that you still have 3 more engines to figure out what you aren't doing correctly before you crash. As best as I can guess an Accusim equipped P-47 will still have a really sucky glide ratio when you fry your one and only.
Back to being only slightly more serious

... I have racked up quite a few hours in the 377 on long hauls, short hauls, really bad weather at night and no land in sight for days types of flights. I can count the Accusim induced panic moments on less than one hand. It may sound odd, but I enjoyed every panic moment and the thumbs up I gave myself when I landed safely or figured the problem out.
What Accusim has done for me is to bring back the original level of excitement I had when I first got into flight simming years ago. Back then I thought how cool it was going to be to "really" learn how to fly a machine. Unfortunantly after 50 or 60 different flight sims over the years that original excitement became tempered by the fact that most of the aircraft in most of the sims are little more than point-n-gos. The only sim aircraft and cockpit that managed to hold my imagination and facination for any length of time, was the F-16 in the Falcon series. Ten years in that cockpit and there was still plently to learn. All those years and I never got bored of being in that jet headed out on a mission and that was in large part to it's cockpit systems complexity.
Now I finally have a civi-sim ride that's just as interesting and goes a long ways in rekindling some of my original facination with flight simming that had become a little faded and jaded over the years.