These are the speeds, indicated, that I get when flying the Spitfire in MSFS in clear conditions:
196 MPH - running low cruise setting of +0 Boost, 2200 RPM
211 MPH - running cruise setting of +2 Boost, 2300 RPM
215 MPH - running cruise setting of +2 Boost, 2400 RPM
223 MPH - running higher cruise setting of +3 Boost, 2400 RPM
If you can fly the Carenado Waco YMF, you can fly this Spitfire. It doesn't require much rudder on takeoff unless you have a crosswind component. As is the case with the real thing, it helps to have some right aileron input on takeoff. Because of the narrow-track landing gear, it might dance a bit on landing, which seems quite close to the real thing.
It can get tiring if you take it on a long-distance flight, as you can never trim it for completely hands-off flying. I seem to recall Peter Teichman once commented that, of flying the Spitfire, Hurricane, P-40 and Mustang, the Spitfire was his least favorite to take on long cross-country flights due to always having to be hands-on flying the aircraft.
Although this was filmed a few years ago, here is another wonderful cockpit video by Dave Hadfield that was just posted a couple days ago, flying the Mike Potter Spitfire Mk.IX based in Canada. Dave provides great descriptions/commentary throughout the video to better understand everything that is happening, including talking through the takeoff and landing. Note how on landing, the aircraft dances around a bit due to the nature of the landing gear - I experienced the exact same thing the other night with one of my landings in the FlyingIron Spitfire in MSFS. Note too that Dave uses reduced power settings with the Spitfire, only using +6 Boost on takeoff and +4 Boost for max-continuous/climb.